Computational protein design for hybrid nanopore sensors

This internship project addresses a key issue of nanopore technology: the integration of the biopore with electronic devices. By designing new proteins that better interface solid-state nanopore technologies, we aim to enable the assembly of a dense array of individually readable nanometer-scaled protein nanopores on a sensor chip. Such a “hybrid nanopore” concept would open the door to next generation DNA and protein sequencing approaches, as well as the development of novel wearable devices and point-of-care technologies for the real-time identification of molecules and biomarkers. In this Master thesis computational protein design will be leveraged to develop versatile hybrid nanopores. To find the best possible fit to solid-state pores, we will use de novo design and high-throughput experiments combined with cutting-edge semiconductor processing techniques. The Master thesis involves both wet lab and computational work with a balance that can be adapted to the candidate expertise/interests. The project proposed is a collaboration between VUB and IMEC. Type of internship : PhD internship, Master internship Duration : 5-6 months Required educational background : Bioscience Engineering, Chemistry/Chemical Engineering, Nanoscience & Nanotechnology, Physics, Electrotechnics/Electrical Engineering, Materials Engineering University promotor : Pol Van Dorpe (KU Leuven) Supervising scientist(s) : For further information or for application, please contact Jose Morales Hellin ( Jose.MoralesHellin@imec.be ) and Koen Martens ( Koen.Martens@imec.be ) The reference code for this position is 2026-INT-073 . Mention this reference code in your application. Applications should include the following information: resume motivation current study Incomplete applications will not be considered